Purpose of the Network

The purpose of the Network is to promote Medical Precision in Neurodegenerative Diseases, with emphasis on their genetic basis, and to achieve progress in this area through:

  • of the creation of a national record – Register of Neurodegenerative Diseases and their Precursor Forms, with a focus on early-preclinical diagnosis that will allow early early therapeutic intervention and, in the second year, clinical trials in people in the early-preclinical stages and not in the clinical phase of the disease or even in the final stages, as is currently the case, due to the lack of diagnostic and prognostic tools. It also focuses on the creation of registries for individual neurodegenerative diseases in Greece.

    The creation of registries for individual neurodegenerative diseases in Greece is an urgent need. These national records with the systematic collection of information can be particularly useful for both public health and current research, and can be used in the future in the light of emerging diagnostic tests, targeted medications and the search for people to participate in clinical studies. Some neurodegenerative diseases are purely genetic (eg Huntington’s disease), others, such as those in the spectrum of frontal degeneration / lateral myotrophic sclerosis, often occur sporadically, but many cases are inherited-genetic. However, the majority of the most common diseases (Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis) occur mainly sporadically and only rarely as inherited forms due to gene mutations with varying degrees of penetration. Therefore, the register will contribute to the more complete mapping and geographical distribution of hereditary degenerative diseases in Greece. It will be very important to record in the Register precursors of neurodegenerative diseases, such as precursors of Parkinson’s disease in the general population, patients with orthopedic REM Sleep Behavior Diosrder (RBD), who are at significant risk of developing Parkinson’s disease or other neurodegenerative disease. type of synuclein disease in the coming years, people with Subjective Mental Disorder, as well as relatives of patients, asymptomatic carriers of genetic mutations, which lead with high penetration to the development of neurodegenerative diseases.
  • the creation of a bank of Biological Material of Neurodegenerative Diseases and their Precursors.

    This action will be closely linked to the Creation of the Register of Neurodegenerative Diseases and their Precursor Forms. The biological samples of the Biobank will correspond to an entry in the Register.
  • of Biochemical analysis of biological material aiming at Precision Medicine
  • of Molecular analysis of biological material aiming at Precision Medicine
  • the provision of free genetic tests for the early-preclinical diagnosis of neurodegenerative diseases
  • of the evolution of bioinformatics
  • the development of models, as well as new biological indicators for neurodegenerative diseases that will allow the application of personalized medical practices
  • of secure collection, analysis, storage and distribution of data in accordance with the provisions of no. 12
  • of the support and development of the developed clinical network in Athens and Thessaloniki and in other big Greek cities
  • the effective management of the results that will emerge from the research with a view to the promotion of Medical Precision and the use of the research for the benefit of Public Health